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Search Results for " connective tissue growth factor "

3

抑制剂 & 化合物

10

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T76804	FG-3019
	FG-3019 (Pamrevlumab)为重组人源化抗体，特异性结合于结缔组织生长因子(CTGF)。适用于特发性肺纤维化(IPF)研究领域。
T28222	5-Hydroxy-1-methylhydantoin HD-003,HD003,5-羟基-1-甲基咪唑啉-2,4-二酮,NZ419,NZ-419,HD 003,NZ 419	Bradykinin Receptor	GPCR/G Protein
	5-Hydroxy-1-methylhydantoin (HD-003) 是一种可能用于治疗肾衰竭的抗氧化剂。它是肌酐代谢物，是一种羟基自由基清除剂，此前已显示通过抑制大鼠慢性肾病的进展来提供肾脏保护。它是一种新型抗氧化药物，可完全抑制 B2-激肽受体(B2KR) 对 VSMC 中高葡萄糖 (25 mM) 刺激的反应，并且还显示可减弱 BK 对 VSMC 重塑的影响。它抑制 BK 诱导的 MAPK 磷酸化增加并减弱 VSMC 中结缔组织生长因子 (CTGF) 蛋白水平的增加。这些研究结果表明，它可能通过其抗氧化特性赋予血管保护免受高葡萄糖浓度和 BK 刺激以改善血管损伤和重塑。
T68302	KD3010 tosylate
	KD-3010 is a peroxisome proliferator-activated receptor delta agonist potentially for the treatment of diabetes and obesity. KD-3010 dramatically ameliorates liver injury induced by carbon tetrachloride (CCl(4)) injections. Deposition of extracellular matrix proteins was lower in the KD3010-treated group than in the vehicle- or GW501516-treated group. Interestingly, profibrogenic connective tissue growth factor was induced significantly by GW501516, but not by KD-3010, following CCl(4) treatmen...

化合物

Cat.No: T76804

5-Hydroxy-1-methylhydantoin

Cat.No: T28222

Synonym: HD-003,HD003,5-羟基-1-甲基咪唑啉-2,4-二酮,NZ419,NZ-419,HD 003,NZ 419

Target: Bradykinin Receptor

KD3010 tosylate

Cat.No: T68302

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01163	CTGF/CCN2 Protein, Human, Recombinant (HEK293, His) CTGF,Connective tissue growth	Human	HEK293 Cells
	Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CYR61/CTGF/NOV) family of secreted matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF has various biological functions, including cell adhesion, migration, proliferation, differentiation, and ECM production, and participates in the development of many organs under normal physio...
TMPJ-01162	CTGF/CCN2 Protein, Human, Recombinant (hFc) IGFBP8,Connective tissue growth <...	Human	HEK293 Cells
	CTGF/CCN2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 67-81 KDa and the accession number is Q5M8T4.
TMPJ-01161	CTGF/CCN2 Protein, Human, Recombinant IGFBP-8,CCN family member 2,IBP-8,Connective ti...	Human	HEK293 Cells
	CTGF/CCN2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 16-25 KDa and the accession number is Q5M8T4.
TMPH-02568	CTGF/CCN2 Protein, Mouse, Recombinant (GST) betaIG-M2,Connective tissue growth	Mouse	E. coli
	Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.
TMPH-01069	CTGF/CCN2 Protein, Human, Recombinant (His) Hypertrophic chondrocyte-specific protein 24,CCN family memb...	Human	E. coli
	Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. CTGF/CCN2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 15.1 kDa and...
TMPY-00117	FGF-16 Protein, Human, Cynomolgus, Recombinant fibroblast growth factor 16	Human,Cynomolgus	Baculovirus Insect Cells
	Fibroblast growth factor 16 (FGF16) is preferentially expressed in the heart after birth, suggesting its regulation is associated with tissue-specific chromatin remodeling and DNA-protein interactions. Mutation of the MEF2 site resulted in a blunting of FGF16 promoter activity in transfected neonatal rat cardiac myocytes, that chromatin remodeling and MEF2 binding in the FGF16 promoter contribute to expression in the postnatal heart. FGF16 involvement in the fine tuning of the human skeleton of ...
TMPK-00672	CTGF/CCN2 Protein, Rhesus macaque, Recombinant (His) CTGRP,CTGF,IBP-8,CCN2,NOV2,HCS24,IGFBP8,Fisp12	Rhesus	HEK293 Cells
	Connective tissue growth factor (CTGF) is a member of the CCN matricellular protein family, consisting of four domains, that regulates the signaling of other growth factors and promotes kidney fibrosis.CTGF can simultaneously interact with several factors with its four domains. The microenvironment differs depending on the types of cells and tissues and differentiation stages of these cells. CTGF/CCN2 Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-His ta...
TMPK-01000	CTGF/CCN2 Protein, Human, Recombinant (His & Avi), Biotinylated CTGF,CCN2,IBP-8,IGFBP8,Fisp12,CTGRP,HCS24,MGC102839,NOV2	Human	HEK293 Cells
	Connective tissue growth factor (CTGF) is a member of the CCN matricellular protein family, consisting of four domains, that regulates the signaling of other growth factors and promotes kidney fibrosis.CTGF can simultaneously interact with several factors with its four domains. The microenvironment differs depending on the types of cells and tissues and differentiation stages of these cells. CTGF/CCN2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells wi...
TMPJ-01005	Lumican Protein, Mouse, Recombinant (His) KSPG lumican,Lumican,Keratan sulfate proteoglycan lumican	Mouse	HEK293 Cells
	Keratan sulfate proteoglycan lumican, mostly known as lumican, belongs to the SLRP class II subfamily and the small leucine-rich proteoglycan (SLRP) family. Lumican binds to laminin. It has positive regulation of transcription from RNA polymerase II promoter and transforming growth factor beta1 production. Lumican is expressed in a variety of tissues, including skin, artery, lung, cornea, kidney, bone, aorta, and articular cartilage. The abnormal connective tissue phenotype seen in the Lumican n...
TMPY-00950	WISP1/CCN4 Protein, Human, Recombinant (His) WISP1c,WISP1i,CCN4,WNT1 inducible signaling pathway protein ...	Human	HEK293 Cells
	CCN4/Wnt-induced secreted protein 1 (WISP1) is a secreted, cysteine-rich, heparin-binding glycoprotein, belonging to the CCN (CTGF/CYR61/NOV) family of growth factors, and is involved in diverse biological functions such as cell growth, adhesion, migration, angiogenesis, tissue repair, and regulation of extracellular matrix. Members of the CCN family demonstrate high structural homology sharing four conserved cysteine-rich modular domains: an IGFBP (insulin-like growth factor-binding) domain, a ...

重组蛋白

CTGF/CCN2 Protein, Human, Recombinant (HEK293, His)

Cat.No: TMPJ-01163

Species: Human

Expression System: HEK293 Cells

CTGF/CCN2 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-01162

Species: Human

Expression System: HEK293 Cells

CTGF/CCN2 Protein, Human, Recombinant

Cat.No: TMPJ-01161

Species: Human

Expression System: HEK293 Cells

CTGF/CCN2 Protein, Mouse, Recombinant (GST)

Cat.No: TMPH-02568

Species: Mouse

Expression System: E. coli

CTGF/CCN2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01069

Species: Human

Expression System: E. coli

FGF-16 Protein, Human, Cynomolgus, Recombinant

Cat.No: TMPY-00117

Species: Human,Cynomolgus

Expression System: Baculovirus Insect Cells

CTGF/CCN2 Protein, Rhesus macaque, Recombinant (His)

Cat.No: TMPK-00672

Species: Rhesus

Expression System: HEK293 Cells

CTGF/CCN2 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-01000

Species: Human

Expression System: HEK293 Cells

Lumican Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01005

Species: Mouse

Expression System: HEK293 Cells

WISP1/CCN4 Protein, Human, Recombinant (His)

Cat.No: TMPY-00950

Species: Human

Expression System: HEK293 Cells

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